Fausto Fernos and co-host (and husband) Marc Felion, the first gay couple to podcast, have crafted the unique and wildly popular Feast of Fools, the first comedy podcast to reach 1 million downloads (in April 2006). Feast of Fools is also one of the first podcasts available on iTunes, is the first gay podcast to reach the all-time top 100 on the iTunes Music Stores, and is one of the first podcasts to create a podcasting widget for OSX.
I don't know what the "is one of the first podcasts available on iTunes" means, but the rest is impressive, no?
I wonder if there's any value in the gay demographic in terms of podvertising. Everyone is so busy measuring age and income - I wonder why nobody's measuring more lifestyle issues. I'm not a statician or marketer, though, so perhaps there's just no money in those stats.
Feast of Fools isn't the first gay podcast by far. The Podcast Network has been carrying Scott Sherman's Gay Parenting Show for well over a year now and I suspect a little googling would turn up more.